Exrreme close-up of a melanoma lesion.
Credit: QIMR
SYDNEY: Two new genes that together double a person's risk of developing melanoma have been discovered by Australian scientists.
A team at at the Queensland Institute of Medical Research in Brisbane, led by Nick Hayward and Grant Montgomery, analysed the genes of almost 6,000 people together with their mole count as part of an international collaboration.
Specific changes in two genes were found to make people more susceptible to developing moles. The researchers went on to show, in another 4,000 people, that the same two genes increased the risk of developing melanoma – the most deadly form of skin cancer.
"These are the first genes found to increase melanoma risk by influencing the number of moles a person has," said Hayward. "This finding improves our understanding of the genetics of melanoma and therefore the molecular pathways that lead to its development.
"It has long been known that having a large number of moles is the biggest risk factor," he added. "Therefore we predicted we would find genes linking moles and melanoma. We now have conclusive genetic evidence that having a large number of moles increases an individual's risk of developing melanoma."
The study, published in today's issue of the British journal, Nature Genetics found that people who carry one of these two gene variants have a 25 per cent increased chance of developing melanoma, while for individuals carrying both variants their risk is doubled.
"In the long term, this research will be useful in developing screening techniques, and will also allow us to identify potential new drug targets and ultimately develop new therapies to treat melanoma," said Hayward.
Moles are normal but people should seek advice from their doctor if they observe any changes in size, colour or shape. People with lots of moles are at a higher risk of developing melanoma and should therefore take extra care to avoid overexposure to ultraviolet radiation.
Australia has the highest incidence of melanoma in the world with more than 10,000 new cases and 1,000 people dying from the disease every year. The northern state of Queensland has the highest incidence in Australia, with seven Queenslanders diagnosed with melanoma every day.
The study involved scientists from the Queensland Institute of Medical Research, King’s College London and Britain's University of Leeds. It was funded by the U.S. National Institutes of Health and the Australian National Health and Medical Research Council and published today in .
