|
|
Remarkable discovery: Hofmann in younger days, pictured holding a model of the hallucinogen LSD. GENEVA: Albert Hofmann, the Swiss chemist who discovered the now-banned hallucinogenic drug LSD that was an icon of the Hippie movement, has died at the age of 102. The scientist, born in Baden in northern Switzerland in 1906, worked for chemicals company Sandoz from 1929 to 1971. He "discovered" LSD by chance (See, The acid test, Cosmos Magazine) while researching medicinal plants, trying to synthesise their active components in the hope of discovering a stimulant for the respiratory and circulatory systems. "Wave of happiness" In 1938 while working on ergot, a fungus that attacks grain, Hofmann isolated the German-named "Lysergsaeure-Diaethylamid," or lysergic acid diethylamide. Five years later, while working in his lab, Hofmann spilled some synthesised LSD onto his hand. The effects were immediate: suffering from dizziness, the scientist cycled home and pedalled into his first "trip." Hofmann later said that a wave of happiness swept over him as he recalled sensations from his childhood. He also began to hallucinate and he felt able to fly. Recognising LSD's therapeutic possibilities, Sandoz commercialised the drug from 1947. It was used to treat psychiatric patients who were in a reactionless state and for whom other drugs were no help. In a book he later wrote – where he dubbed LSD his "problem child" – Hofmann said he never envisaged the success it would achieve with young sensation-seekers. In the 1960s, LSD, or acid, was widely used by writers, artists and musicians, particularly in the United States. It even gave rise to the art form known as 'psychedelic art.' Therapeutic use Bands such as The Beatles became enthusiastic consumers of LSD and its psychedelic influence permeates their work from the 1966 album Revolver onwards – though Paul McCartney has always denied that their 1967 song "Lucy in the Sky with Diamonds" was a reference to the drug. U.S. authorities banned the drug in 1966 and it subsequently became illegal worldwide, even for therapeutic use. Like all hallucinogenic drugs, LSD can cause permanent damage if the dose taken is too high. It only takes one 10,000th of a gram of LSD to produce hallucinations. However, in recent years some scientists have found that studying the effects of LSD in the brain can help in finding improved treatments for schizophrenia. Despite his notoriety, Hofmann always sought to play down his discovery and cautioned against the recreational use of LSD. "I'm just an ordinary Swiss, who likes the simple things in life," he told the Tages Anzeiger newspaper on his 100th birthday in 2006. Readers' comments |
COSMOS newsletter!Receive regular updates highlighting the latest in science from COSMOS. Latest News |
Goodbye to a great chemist.
Hopefully Hoffmanns death will prompt more awareness into psychedelics, hence provide more reasearch into these unique 'drugs of distinction'.
LSD research.
The 5-HT2A receptor clearly plays an essential role in cognitive processing, including working memory, and
ligands for this receptor may be extremely useful tools for future cognitive neuroscience research. In addition, it appears entirely possible that
utility may still emerge for the use of hallucinogens in treating alcoholism, substance abuse, and certain psychiatric disorders